The highly pathogenic coronavirus, COVID-19, emerges in China in 2019, and its rapid national and international spread creates a global health emergency. Coronaviruses use their spike proteins to select and enter target cells and insights into COVID-19 spike (S)-driven entry might facilitate the assessment of pandemic potential and reveal therapeutic targets. COVID-19 coronavirus and the SARS-coronavirus share central biological properties which can guide risk assessment and intervention according to the article published in bioRxiv.
