The novel coronavirus COVID-19 uses the SARS-coronavirus receptor ACE2 and TMPRSS2 a cellular protease for entry into target cells

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The highly pathogenic coronavirus, COVID-19, emerges in China in 2019, and its rapid national and international spread creates a global health emergency. Coronaviruses use their spike proteins to select and enter target cells and insights into COVID-19 spike (S)-driven entry might facilitate the assessment of pandemic potential and reveal therapeutic targets. COVID-19 coronavirus and the SARS-coronavirus share central biological properties which can guide risk assessment and intervention according to the article published in bioRxiv.

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